Cryo-Electron Microscopy: A Powerful Tool for Visualizing the Structure of Macromolecules
Cryo-electron microscopy (cryo-EM) is a technique used to obtain high-resolution structural information about biomolecules. While electron microscopy has been used since the 1930s to image thin biological specimens, the development of cryo-EM in the late 20th century revolutionized structural biology. By rapidly freezing biomolecules embedded in